Suppressor of hairless protein (Su (H)) Recombinant Protein | Su(H) recombinant protein

Recombinant Drosophila melanogaster Suppressor of hairless protein (Su (H)), partial

• Gene Names: Su(H); anon-WO0257455.3; BG:DS00929.10; br7; C; CBF1; CG3497; CSL; D; DmelCG3497; dRBP-Jk; dRBP-JK; dRBP-J[[Kappa]]; E(H); FTZ-F2; l(1)br7; l(2)35Bh; l(2)br7; l(2)k07904; oss; RBJK_DROME; RBP-J kappa; RBP-Jkappa; RBP-J[[Kappa]]; su(H); Su(h); SU(H); SuH; SUH; Su
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Suppressor of hairless protein (Su (H)); Recombinant Drosophila melanogaster Suppressor of hairless protein (Su (H)); partial; Su(H) recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 594

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 665408129
• NCBI GeneID: 34881
• NCBI Accession #: NP_001285948.1
• NCBI GenBank Nucleotide #: NM_001299019.1
• UniProt Accession #: P28159; Q3S1M8; Q9TVK8; Q9TVY7; Q9TW34; Q9U8F9; Q9V446
• Molecular Weight: 66,924 Da
• NCBI Official Full Name: suppressor of hairless, isoform C
• NCBI Official Synonym Full Names: Suppressor of Hairless
• NCBI Official Symbol: Su(H)
• NCBI Official Synonym Symbols: anon-WO0257455.3; BG:DS00929.10; br7; C; CBF1; CG3497; CSL; D; DmelCG3497; dRBP-Jk; dRBP-JK; dRBP-J[[Kappa]]; E(H); FTZ-F2; l(1)br7; l(2)35Bh; l(2)br7; l(2)k07904; oss; RBJK_DROME; RBP-J kappa; RBP-Jkappa; RBP-J[[Kappa]]; su(H); Su(h); SU(H); SuH; SUH; Su
• NCBI Protein Information: CG3497 gene product from transcript CG3497-RA
• UniProt Protein Name: Suppressor of hairless protein
• Protein Family: Suppressor of hairless protein
• UniProt Gene Name: Su(H)
• UniProt Synonym Gene Names: dRBP-JK

Uniprot Description

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:21262215, PubMed:1617729, PubMed:8674407, PubMed:10673509). Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:10673509). Acts as a transcriptional repressor when it is not associated with Notch proteins (PubMed:10673509). When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes (PubMed:10673509). Required for transcription of Sim (PubMed:10673509). Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence (PubMed:1744127, PubMed:1617730, PubMed:1617729). Required for neurogenesis in imaginal disks (PubMed:1617730, PubMed:7813798). In the larval brain, might play a role as a transducer of Notch signaling during type II neuroblast development (PubMed:21262215). Also functions independently of the Notch pathway, in the development of the bristle sensory organ precursor cell (PubMed:12642500).