Lethal (3)malignant brain tumor-like protein 1 Recombinant Protein | L3mbtl1 recombinant protein

Recombinant Mouse Lethal (3)malignant brain tumor-like protein 1 , partial

• Gene Names: L3mbtl1; L3mbtl; mKIAA0681; C630004G01
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lethal (3)malignant brain tumor-like protein 1; Recombinant Mouse Lethal (3)malignant brain tumor-like protein 1; partial; L3mbtl1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 826

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 124486779
• NCBI GeneID: 241764
• NCBI Accession #: NP_001074807.1
• NCBI GenBank Nucleotide #: NM_001081338.2
• UniProt Accession #: A2A5N8; Q5DU20
• Molecular Weight: 91,781 Da
• NCBI Official Full Name: lethal(3)malignant brain tumor-like protein 1
• NCBI Official Synonym Full Names: L3MBTL1 histone methyl-lysine binding protein
• NCBI Official Symbol: L3mbtl1
• NCBI Official Synonym Symbols: L3mbtl; mKIAA0681; C630004G01
• NCBI Protein Information: lethal(3)malignant brain tumor-like protein 1
• UniProt Protein Name: Lethal(3)malignant brain tumor-like protein 1
• Protein Family: Lethal(3)malignant brain tumor-like protein
• UniProt Gene Name: L3mbtl1
• UniProt Synonym Gene Names: Kiaa0681; L3mbt; L3mbtl; H-l(3)mbt; H-l(3)mbt protein; L(3)mbt-like

Uniprot Description

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis ().