CTD kinase subunit alpha (lsk1) Recombinant Protein | lsk1 recombinant protein

Recombinant Schizosaccharomyces pombe CTD kinase subunit alpha (lsk1), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: CTD kinase subunit alpha (lsk1); Recombinant Schizosaccharomyces pombe CTD kinase subunit alpha (lsk1); partial; lsk1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 593

• Species: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 19115305
• NCBI GeneID: 2541672
• NCBI Accession #: NP_594393.1
• NCBI GenBank Nucleotide #: NM_001019816.2
• UniProt Accession #: O14098
• Molecular Weight: 67,366 Da
• NCBI Official Full Name: P-TEFb-associated cyclin-dependent protein kinase Lsk1
• NCBI Official Symbol: lsk1
• NCBI Protein Information: P-TEFb-associated cyclin-dependent protein kinase Lsk1
• UniProt Protein Name: CTD kinase subunit alpha
• UniProt Gene Name: lsk1
• UniProt Synonym Gene Names: CTDK-I subunit alpha

Uniprot Description

Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (). Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD. Required for nuclear localization of ctk2/lsc1. Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in response to perturbation of the actomyosin ring. Acts in parallel to clp1 to promote actomyosin ring stability upon cytokinesis checkpoint activation.