Serine/threonine-protein kinase US3 homolog (66) Recombinant Protein | ORF66 recombinant protein
Recombinant Varicella-zoster virus Serine/threonine-protein kinase US3 homolog (66)
NCBI and Uniprot Product Information
Uniprot Description
Function: Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. Phosphorylates proteins 24 and 27, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface. Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing
By similarity. Downregulates class I major histocompatibility complex (MHC-I) surface expression. Additionally, phosphorylates IE62 and targets it to the cytoplasm. The nuclear exclusion of IE62 enables the packaging of abundant levels of IE62 into virions. Ref.5 Ref.6 Ref.7 Ref.8
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subcellular location: Host cytoplasm
By similarity. Host nucleus
By similarity.
Post-translational modification: Phosphorylated by ORF47; this phosphorylation regulates subsequent phosphorylation of proteins 24 and 27 by ORF66. Autophosphorylated
By similarity. Ref.4 Ref.8
Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.
Research Articles on ORF66
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Product Notes
The ORF66 66 (Catalog #AAA1117686) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-393aa; full length protein. The amino acid sequence is listed below: MNDVDATDTF VGQGKFRGAI STSPSHIMQT CGFIQQMFPV EMSPGIESED DPNYDVNMDI QSFNIFDGVH ETEAEASVAL CAEARVGINK AGFVILKTFT PGAEGFAFAC MDSKTCEHVV IKAGQRQGTA TEATVLRALT HPSVVQLKGT FTYNKMTCLI LPRYRTDLYC YLAAKRNLPI CDILAIQRSV LRALQYLHNN SIIHRDIKSE NIFINHPGDV CVGDFGAACF PVDINANRYY GWAGTIATNS PELLARDPYG PAVDIWSAGI VLFEMATGQN SLFERDGLDG NCDSERQIKL IIRRSGTHPN EFPINPTSNL RRQYIGLAKR SSRKPGSRPL WTNLYELPID LEYLICKMLS FDARHRPSAE VLLNHSVFQT LPDPYPNPME VGD. It is sometimes possible for the material contained within the vial of "Serine/threonine-protein kinase US3 homolog (66), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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