Protein Wnt-1 (cwn-1) Recombinant Protein | cwn-1 recombinant protein
Recombinant Caenorhabditis elegans Protein Wnt-1 (cwn-1)
NCBI and Uniprot Product Information
Uniprot Description
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1 (PubMed:17942487). Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219). Also acts with the Wnt ligand egl-20 to direct HSN neuron migration (PubMed:16516839). Acts through the Wnt receptor cfz-2 to direct ALM migration (PubMed:16109397). Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397). In addition, together with Wnt ligand cwn-2, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603). Probably by activating the Wnt/Frizzled pathway, may regulate vulva development (PubMed:17942487). May act redundantly with other Wnt ligands such as cwn-2 and mom-2 to control seam cell polarity (PubMed:22022276).
Research Articles on cwn-1
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Product Notes
The cwn-1 cwn-1 (Catalog #AAA1113553) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 30-372, Full length. The amino acid sequence is listed below: ANRFDRDKPG TSCKSLKGLT RRQMRFCKKN IDLMESVRSG SLAAHAECQF QFHKRRWNCT LIDPVTHEVI PDVFLYENTR ESAFVHAISS AAVAYKVTRD CARGISERCG CDYSKNDHSG KSQFQYQGCS DNVKFGIGVS KEFVDSAQRR VLMMKDDNGT SLLGPSQLSA DGMHMINLHN NQAGRQVLEK SLRRECKCHG MSGSCEMRTC WDSLPNFRHI GMAIKDKFDG AAEVKVVKED GIEKPRIVMK NSQFKRHTNA DLVYMTPSPD FCESDPLRGI LGTKGRQCTL APNAIDDCSL LCCGRGYEKK VQIVEEKCNC KFIYCCEVRC EPCQKRIEKY LCL. It is sometimes possible for the material contained within the vial of "Protein Wnt-1 (cwn-1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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