Alpha-latrotoxin-Lhe1a Recombinant Protein | Alpha-LTX-Lhe1a recombinant protein
Recombinant Latrodectus hesperus Alpha-latrotoxin-Lhe1a
NCBI and Uniprot Product Information
Uniprot Description
Function: Presynaptic neurotoxin that induces exhaustive neurotransmitter release from vertebrate (but not invertebrate) nerve terminals and endocrine cells. Binds to neurexin-1-alpha (NRXN1), latrophilin-1 (LPHN1), and receptor-type tyrosine-protein phosphatase S (PTPRS), and induces neurotransmitter exocytosis through two calcium-dependent mechanisms (membrane pore formation and signaling via latrophilin) and a yet to be defined calcium-independent mechanism. Induces rapid muscle contracture and loss of twitch tension when added to the isolated and indirectly stimulated chick biventer cervicis nerve-muscle preparation
By similarity.
Subunit structure: Homotetramer; Homotetramerization is triggered by calcium and is responsible for non-vesicular release and calcium-dependent vesicular exocytosis
By similarity.
Subcellular location: Secreted. Target cell membrane
By similarity. Note: Forms a membrane channel in the prey.
Tissue specificity: Expressed by the venom gland.
Post-translational modification: Processed by furin-like proteases at both the N- and C-termini.Contains 1 disulfide bond
By similarity.
Miscellaneous: Is the main neurotoxin responsible for the human envenomation syndrome known as latrodectism that results from bites by Latrodectus species.Iso and Leu residues are assigned by comparison with orthologs.
Sequence similarities: Belongs to the latrotoxin family.Contains 22 ANK repeats.
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Product Notes
The Alpha-latrotoxin-Lhe1a alpha-ltx-lhe1a (Catalog #AAA1105706) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-22aa; full length protein. The amino acid sequence is listed below: YAVQYASETL FSKSPEININ ER. It is sometimes possible for the material contained within the vial of "Alpha-latrotoxin-Lhe1a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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