Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Recombinant Protein | PRDM6 recombinant protein

Recombinant Bovine Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Putative histone-lysine N-methyltransferase PRDM6 (PRDM6); Recombinant Bovine Putative histone-lysine N-methyltransferase PRDM6 (PRDM6); partial; PRDM6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 590

• Species: Bovine
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 157074028
• NCBI GeneID: 519857
• NCBI Accession #: NP_001096725.1
• NCBI GenBank Nucleotide #: NM_001103255.2
• UniProt Accession #: A6QPM3
• Molecular Weight: 63,989 Da
• NCBI Official Full Name: putative histone-lysine N-methyltransferase PRDM6
• NCBI Official Synonym Full Names: PR/SET domain 6
• NCBI Official Symbol: PRDM6
• NCBI Protein Information: putative histone-lysine N-methyltransferase PRDM6
• UniProt Protein Name: Putative histone-lysine N-methyltransferase PRDM6
• Protein Family: Putative histone-lysine N-methyltransferase
• UniProt Gene Name: PRDM6

Uniprot Description

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.