Phospholemman (FXYD1) Recombinant Protein | FXYD1 recombinant protein

Recombinant Human Phospholemman (FXYD1)

• Gene Names: FXYD1; PLM
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Phospholemman (FXYD1); Recombinant Human Phospholemman (FXYD1); FXYD1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 21-35
• Sequence: ESPKEHDPFTYDYQS
• Sequence Length: 92

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Related Product Information for FXYD1 recombinant protein

FXYD1; PLM

NCBI and Uniprot Product Information

• NCBI GI #: 11612672
• NCBI GeneID: 5348
• NCBI Accession #: NP_005022.2
• NCBI GenBank Nucleotide #: NM_005031.3
• UniProt Accession #: O00168; A8K196
• Molecular Weight: 10,441 Da
• NCBI Official Full Name: phospholemman
• NCBI Official Synonym Full Names: FXYD domain containing ion transport regulator 1
• NCBI Official Symbol: FXYD1
• NCBI Official Synonym Symbols: PLM
• NCBI Protein Information: phospholemman
• UniProt Protein Name: Phospholemman
• Protein Family: Phospholemman
• UniProt Gene Name: FXYD1
• UniProt Synonym Gene Names: PLM
• UniProt Entry Name: PLM_HUMAN

NCBI Description

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]

Uniprot Description

PLM: a protein of the FXYD family of small ion transport regulators or channels. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May have a functional role in muscle contraction. Major plasma membrane substrate for PKA and PKC in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation.Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining.

Protein type: Membrane protein, integral; Cell surface; Channel, misc.

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: integral to plasma membrane; plasma membrane; sodium:potassium-exchanging ATPase complex; sarcolemma

Molecular Function: chloride channel activity; sodium channel regulator activity

Biological Process: cellular calcium ion homeostasis; muscle contraction; chloride transport; transmembrane transport; regulation of heart contraction