MAP kinase-activating death domain protein (Madd) Recombinant Protein | Madd recombinant protein

Recombinant Rat MAP kinase-activating death domain protein (Madd) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: MAP kinase-activating death domain protein (Madd); Recombinant Rat MAP kinase-activating death domain protein (Madd); partial; Madd recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,602

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Madd recombinant protein

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. This protein is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 16758360
• NCBI GeneID: 94193
• NCBI Accession #: NP_446037.1
• NCBI GenBank Nucleotide #: NM_053585.1
• UniProt Accession #: O08873
• Molecular Weight: 177,992 Da
• NCBI Official Full Name: MAP kinase-activating death domain protein
• NCBI Official Synonym Full Names: MAP-kinase activating death domain
• NCBI Official Symbol: Madd
• NCBI Protein Information: MAP kinase-activating death domain protein
• UniProt Protein Name: MAP kinase-activating death domain protein
• Protein Family: Malonyl-S-ACP:biotin-protein carboxyltransferase
• UniProt Gene Name: Madd

NCBI Description

GDP/GTP exchange protein (GEP) for Rab3 subfamily small G proteins; may play a role in intracellular vesicle trafficking [RGD, Feb 2006]

Uniprot Description

Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis).