Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (CTDSP2) Recombinant Protein | CTDSP2 recombinant protein

Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (CTDSP2)

Cat. Num. AAA1063605

• Gene Names: CTDSP2; OS4; PSR2; SCP2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (CTDSP2); Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (CTDSP2); CTDSP2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-271, Full length protein
• Sequence: MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRNIFKALFCCFRAQHVGQSSSSTELAAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGQLRAP
• Sequence Length: 271

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 93004102
• NCBI GeneID: 10106
• NCBI Accession #: NP_005721.3
• NCBI GenBank Nucleotide #: NM_005730.3
• UniProt Accession #: O14595; Q53ZR2; Q6NZY3; Q9UEX1; A8K5H4
• Molecular Weight: 30,664 Da
• NCBI Official Full Name: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
• NCBI Official Synonym Full Names: CTD small phosphatase 2
• NCBI Official Symbol: CTDSP2
• NCBI Official Synonym Symbols: OS4; PSR2; SCP2
• NCBI Protein Information: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
• UniProt Protein Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
• Protein Family: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase
• UniProt Gene Name: CTDSP2
• UniProt Synonym Gene Names: NIF2; OS4; SCP2; NLI-interacting factor 2; SCP2

Uniprot Description

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.