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SDS-PAGE

NF-kappa-B-repressing factor (NKRF) Recombinant Protein | NKRF recombinant protein

Recombinant Human NF-kappa-B-repressing factor (NKRF)

Gene Names
NKRF; NRF; ITBA4
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
NF-kappa-B-repressing factor (NKRF); Recombinant Human NF-kappa-B-repressing factor (NKRF); NF-kappa-B-repressing factor; NFkB-repressing factor; Protein ITBA4; Transcription factor NRF; NKRF recombinant protein
Ordering
For Research Use Only!
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
4-688aa; Partial
Sequence
ILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVKSSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQ
Sequence Length
690
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

SDS-PAGE
Related Product Information for NKRF recombinant protein
Interacts with a specific negative regulatory elent (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
Product Categories/Family for NKRF recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
81.1 kDa
NCBI Official Full Name
NF-kappa-B-repressing factor isoform 1
NCBI Official Synonym Full Names
NFKB repressing factor
NCBI Official Symbol
NKRF
NCBI Official Synonym Symbols
NRF; ITBA4
NCBI Protein Information
NF-kappa-B-repressing factor; transcription factor NRF
UniProt Protein Name
NF-kappa-B-repressing factor
UniProt Gene Name
NKRF
UniProt Synonym Gene Names
ITBA4; NRF; NFkB-repressing factor
UniProt Entry Name
NKRF_HUMAN

NCBI Description

This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

NKRF: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.

Protein type: Nucleolus; Transcription, coactivator/corepressor; RNA-binding

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: endoplasmic reticulum; nucleolus; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent

Research Articles on NKRF

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Product Notes

The NKRF nkrf (Catalog #AAA1031964) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 4-688aa; Partial. The amino acid sequence is listed below: ILQMAEGIDI GEMPSYDLVL SKPSKGQKRH LSTCDGQNPP KKQAGSKFHA RPRFEPVHFV ASSSKDERQE DPYGPQTKEV NEQTHFASMP RDIYQDYTQD SFSIQDGNSQ YCDSSGFILT KDQPVTANMY FDSGNPAPST TSQQANSQST PEPSPSQTFP ESVVAEKQYF IEKLTATIWK NLSNPEMTSG SDKINYTYML TRCIQACKTN PEYIYAPLKE IPPADIPKNK KLLTDGYACE VRCQNIYLTT GYAGSKNGSR DRATELAVKL LQKRIEVRVV RRKFKHTFGE DLVVCQIGMS SYEFPPALKP PEDLVVLGKD ASGQPIFNAS AKHWTNFVIT ENANDAIGIL NNSASFNKMS IEYKYEMMPN RTWRCRVFLQ DHCLAEGYGT KKTSKHAAAD EALKILQKTQ PTYPSVKSSQ CHTGSSPRGS GKKKDIKDLV VYENSSNPVC TLNDTAQFNR MTVEYVYERM TGLRWKCKVI LESEVIAEAV GVKKTVKYEA AGEAVKTLKK TQPTVINNLK KGAVEDVISR NEIQGRSAEE AYKQQIKEDN IGNQLLRKMG WTGGGLGKSG EGIREPISVK EQHKREGLGL DVERVNKIAK RDIEQIIRNY ARSESHTDLT FSRELTNDER KQIHQIAQKY GLKSKSHGVG HDRYLVVGRK RRKEDLLDQL KQEGQVGHYE LVMPQ. It is sometimes possible for the material contained within the vial of "NF-kappa-B-repressing factor (NKRF), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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