Modulator of FtsH protease YccA (yccA) Recombinant Protein | yccA recombinant protein
Recombinant Escherichia coli Modulator of FtsH protease YccA (yccA)
NCBI and Uniprot Product Information
NCBI Description
YccA is a substrate or modulator of FtsH-mediated proteolysis. [More information is available at EcoCyc: EG11113].
Uniprot Description
Function: Negatively modulates the activity of the FtsH protease for membrane substrates. Overexpression or stabilizing YccA counteracts the FtsH-mediated degradation of SecY when the SecYEG preprotein translocator is jammed. Ref.8
Subunit structure: Both wild-type and the yccA11 mutant interact with the FtsH/HflKC complex.
Subcellular location: Cell inner membrane; Multi-pass membrane protein. Note: There are conflicting results regarding the localization of the C-terminus of this protein; Ref.6 gives the C-terminus in the periplasm while Ref.7 gives the C-terminus in the cytoplasm. We show the periplasmic location.
Induction: Regulated in a Cpx-dependent fashion. Ref.8
Post-translational modification: YccA is processively degraded by FtsH; degradation initiates via the approximately 20 residue N-terminal tail in a sequence non-specific manner. The deletion mutant yccA11 is resistant to FtsH-mediated degradation, probably because it is too short to be degraded by FtsH.
Disruption phenotype: No effect on SecY degradation. Ref.5
Sequence similarities: Belongs to the BI1 family.
Research Articles on yccA
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Product Notes
The yccA ycca (Catalog #AAA1027616) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-219. The amino acid sequence is listed below: MDRIVSSSHD RTSLLSTHKV LRNTYFLLSL TLAFSAITAT ASTVLMLPSP GLILTLVGMY GLMFLTYKTA NKPTGIISAF AFTGFLGYIL GPILNTYLSA GMGDVIAMAL GGTALVFFCC SAYVLTTRKD MSFLGGMLMA GIVVVLIGMV ANIFLQLPAL HLAISAVFIL ISSGAILFET SNIIHGGETN YIRATVSLYV SLYNIFVSLL SILGFASRD. It is sometimes possible for the material contained within the vial of "Modulator of FtsH protease YccA (yccA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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