HERV-FRD_6p24.1 provirus ancestral Env polyprotein (ERVFRD-1) Recombinant Protein | ERVFRD-1 recombinant protein

Recombinant Human HERV-FRD_6p24.1 provirus ancestral Env polyprotein (ERVFRD-1), partial

Cat. Num. AAA1020059

• Gene Names: ERVFRD-1; envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: HERV-FRD_6p24.1 provirus ancestral Env polyprotein (ERVFRD-1); Recombinant Human HERV-FRD_6p24.1 provirus ancestral Env polyprotein (ERVFRD-1); partial; ERVFRD-1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 16-478
• Sequence: AYRHP DFPLLEKAQQ LLQSTGSPYS TNCWLCTSSS TETPGTAYPA SPREWTSIEA ELHISYRWDP NLKGLMRPAN SLLSTVKQDF PDIRQKPPIF GPIFTNINLM GIAPICVMAK RKNGTNVGTL PSTVCNVTFT VDSNQQTYQT YTHNQFRHQP RFPKPPNITF PQGTLLDKSS RFCQGRPSSC STRNFWFRPA DYNQCLQISN LSSTAEWVLL DQTRNSLFWE NKTKGANQSQ TPCVQVLAGM TIATSYLGIS AVSEFFGTSL TPLFHFHIST CLKTQGAFYI CGQSIHQCLP SNWTGTCTIG YVTPDIFIAP GNLSLPIPIY GNSPLPRVRR AIHFIPLLAG LGILAGTGTG IAGITKASLT YSQLSKEIAN NIDTMAKALT TMQEQIDSLA AVVLQNRRGL DMLTAAQGGI CLALDEKCCF WVNQSGKVQD NIRQLLNQAS SLRERATQGW LNWEGTWK
• Sequence Length: 463

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 46485773
• NCBI GeneID: 405754
• NCBI Accession #: NP_997465.1
• NCBI GenBank Nucleotide #: NM_207582.2
• UniProt Accession #: P60508
• Molecular Weight: 59,523 Da
• NCBI Official Full Name: syncytin-2 preproprotein
• NCBI Official Synonym Full Names: endogenous retrovirus group FRD member 1, envelope
• NCBI Official Symbol: ERVFRD-1
• NCBI Official Synonym Symbols: envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD
• NCBI Protein Information: syncytin-2
• UniProt Protein Name: Syncytin-2
• Protein Family: Syncytin
• UniProt Gene Name: ERVFRD-1
• UniProt Synonym Gene Names: ERVFRDE1; SU; TM

NCBI Description

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]

Uniprot Description

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).