Ornithine decarboxylase antizyme 1 (OAZ1) Recombinant Protein | OAZ1 recombinant protein

Recombinant Mesocricetus auratus Ornithine decarboxylase antizyme 1 (OAZ1)

Cat. Num. AAA1014286

• Gene Names: Oaz1; OAZ; ODC-Az
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ornithine decarboxylase antizyme 1 (OAZ1); Recombinant Mesocricetus auratus Ornithine decarboxylase antizyme 1 (OAZ1); OAZ1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-222, full length protein
• Sequence: VKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRAALHCCSNLGPGPRWCSYVPHPPLKIPGGRGNSQRDHSLSASVLYSDERLNVTEEPTANDKTRVLSIQSRLTEAKQVTWRAVWNGGGLYIELPAGPSPEGSKDSFAALLEFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLERED
• Sequence Length: 221

• Species: Mesocricetus auratus (Golden hamster)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 577861059
• NCBI GeneID: 101826304
• NCBI Accession #: NP_001268250.2
• NCBI GenBank Nucleotide #: NM_001281321.2
• UniProt Accession #: P70112
• Molecular Weight: 24,675 Da
• NCBI Official Full Name: ornithine decarboxylase antizyme 1
• NCBI Official Symbol: Oaz1
• NCBI Official Synonym Symbols: OAZ; ODC-Az
• NCBI Protein Information: ornithine decarboxylase antizyme 1
• UniProt Protein Name: Ornithine decarboxylase antizyme 1
• Protein Family: Ornithine decarboxylase antizyme
• UniProt Gene Name: OAZ1
• UniProt Synonym Gene Names: OAZ; ODC-Az

NCBI Description

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014]

Uniprot Description

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.