Cyclic nucleotide-gated ion channel 1 (CNGC1) Recombinant Protein | CNGC1 recombinant protein

Recombinant Arabidopsis thaliana Cyclic nucleotide-gated ion channel 1 (CNGC1)

• Gene Names: CNGC1; ATCNGC1; CNGC1; cyclic nucleotide gated channel 1; CYCLIC NUCLEOTIDE-GATED CHANNEL 1; MFH8.6; MFH8_6
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cyclic nucleotide-gated ion channel 1 (CNGC1); Recombinant Arabidopsis thaliana Cyclic nucleotide-gated ion channel 1 (CNGC1); Recombinant Cyclic nucleotide-gated ion channel 1 (CNGC1); Cyclic nucleotide-gated ion channel 1; AtCNGC1; Cyclic nucleotide- and calmodulin-regulated ion channel 1; CNGC1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-716
• Sequence: MNFRQEKFVRFQDWKSDKTSSDVEYSGKNEIQTGIFQRTISSISDKFYRSFESSSARIKLFKRSYKSYSFKEAVSKGIGSTHKILDPQGPFLQRWNKIFVLACIIAVSLDPLFFYVPIIDDAKKCLGIDKKMEITASVLRSFTDVFYVLHIIFQFRTGFIAPSSRVFGRGVLVEDKREIAKRYLSSHFIIDILAVLPLPQMVILIIIPHMRGSSSLNTKNMLKFIVFFQYIPRFIRIYPLYKEVTRTSGILTETAWAGAAFNLFLYMLASHVFGAFWYLFSIERETVCWKQACERNNPPCISKLLYCDPETAGGNAFLNESCPIQTPNTTLFDFGIFLDALQSGVVESQDFPQKFFYCFWWGLQNLSSLGQNLKTSTYIWEICFAVFISIAGLVLFSFLIGNMQTYLQSTTTRLEEMRVKRRDAEQWMSHRLLPENLRKRIRRYEQYKWQETRGVDEENLLSNLPKDLRRDIKRHLCLALLMRVPMFEKMDEQLLDALCDRLQPVLYTEESYIVREGDPVDEMLFIMRGKLLTITTNGGRTGFLNSEYLGAGDFCGEELLTWALDPHSSSNLPISTRTVRALMEVEAFALKADDLKFVASQFRRLHSKQLRHTFRYYSQQWKTWAACFIQAAWRRYIKKKLEESLKEEENRLQDALAKEACGSSPSLGATIYASRFAANILRTIRRSGSVRKPRMPERMPPMLLQKPAEPDFNSDD
• Sequence Length: 716

• Species: Arabidopsis thaliana (Mouse-ear cress)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 15238657
• NCBI GeneID: 835393
• NCBI Accession #: NP_200125.1
• NCBI GenBank Nucleotide #: NM_124692.3
• UniProt Accession #: O65717; T51354
• Molecular Weight: 83,097 Da
• NCBI Official Full Name: cyclic nucleotide-gated ion channel 1
• NCBI Official Symbol: CNGC1
• NCBI Official Synonym Symbols: ATCNGC1; CNGC1; cyclic nucleotide gated channel 1; CYCLIC NUCLEOTIDE-GATED CHANNEL 1; MFH8.6; MFH8_6
• NCBI Protein Information: cyclic nucleotide-gated ion channel 1
• UniProt Protein Name: Cyclic nucleotide-gated ion channel 1
• Protein Family: Cyclic nucleotide-gated ion channel
• UniProt Gene Name: CNGC1
• UniProt Synonym Gene Names: AtCNGC1
• UniProt Entry Name: CNGC1_ARATH

Uniprot Description

Function: Acts as cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K+, Na+ and Pb2+. Ref.7 Ref.9

Subunit structure: Homotetramer or heterotetramer

Potential. Binds calmodulin-2/3/5 with a higher affinity than calmodulin-1/4.

Subcellular location: Cell membrane; Multi-pass membrane protein

Potential.

Tissue specificity: Expressed in the whole plant but only weakly in roots.

Domain: The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation

By similarity. Ref.6

Disruption phenotype: Plants exhibit an improved tolerance to Pb2+. Ref.7

Sequence similarities: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. [View classification]Contains 1 cyclic nucleotide-binding domain.Contains 1 IQ domain.