740 Y-P(TFA), Inhibitor | 740Y-P(TFA), inhibitor
740 Y-P(TFA)
Purity
98.89%
Synonyms
740 Y-P(TFA); PDGFR 740Y-P(TFA); 740YPDGFR(TFA); 740Y-P(TFA); inhibitor
Purity/Purification
98.89%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In Vitro
740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide [1]. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin[2].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for 740Y-P(TFA), inhibitor
740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.
Product Categories/Family for 740Y-P(TFA), inhibitor
References
Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52.
Williams EJ, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci. 1999 Apr;13(4):272-80.
Williams EJ, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci. 1999 Apr;13(4):272-80.
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Product Notes
The 740Y-P(TFA) (Catalog #AAA5764261) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "740 Y-P(TFA), Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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