Human vacuolar protein sorting 36 homolog (S. cerevisiae) ELISA Kit | VPS36 elisa kit

Human Vacuolar protein-sorting-associated protein 36, VPS36 ELISA Kit

Cat. Num. AAA9335056

• Gene Names: VPS36; EAP45; C13orf9; CGI-145
• Reactivity: Human
• Synonyms: vacuolar protein sorting 36 homolog (S. cerevisiae); Human Vacuolar protein-sorting-associated protein 36; VPS36 ELISA Kit; Human Vacuolar protein-sorting-associated protein 36 (VPS36) ELISA kit; C13orf9; CGI-145; DKFZp781E0871; EAP45; ELL-associated protein; 45 kDa; vacuolar protein sorting 36; VPS36 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 532164692
• NCBI GeneID: 51028
• NCBI Accession #: NP_001269098.1
• NCBI GenBank Nucleotide #: NM_001282169.1
• UniProt Accession #: Q86VN1; Q3ZCV7; Q5H9S1; Q5VXB6; Q9H8Z5; Q9Y3E3; A8K125
• Molecular Weight: 43,817 Da
• NCBI Official Full Name: vacuolar protein-sorting-associated protein 36 isoform 3
• NCBI Official Synonym Full Names: vacuolar protein sorting 36 homolog (S. cerevisiae)
• NCBI Official Symbol: VPS36
• NCBI Official Synonym Symbols: EAP45; C13orf9; CGI-145
• NCBI Protein Information: vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36; ELL-associated protein of 45 kDa
• UniProt Protein Name: Vacuolar protein-sorting-associated protein 36
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS36
• UniProt Synonym Gene Names: C13orf9; EAP45; CGI-145
• UniProt Entry Name: VPS36_HUMAN

NCBI Description

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

Uniprot Description

VPS36: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. Belongs to the VPS36 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: membrane; lysosome; late endosome; cytosol; nucleus; endosome

Molecular Function: protein binding; ubiquitin binding; phosphatidylinositol 3-phosphate binding

Biological Process: protein transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; endosome transport