Human testis expressed 14 ELISA Kit | TEX14 elisa kit
Human Testis-expressed protein 14, TEX14 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Uniprot Description
TEX14: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro. Belongs to the protein kinase superfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Cancer Testis Antigen (CTA); Other group; NKF5 family
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: kinetochore; intercellular bridge; cell; cytoplasm; midbody
Molecular Function: protein binding; protein kinase binding; ATP binding; protein kinase activity
Biological Process: cell division; intercellular bridge organization and biogenesis; mitotic cell cycle spindle assembly checkpoint; mitotic sister chromatid separation; attachment of spindle microtubules to kinetochore; negative regulation of protein binding; male meiosis; protein amino acid phosphorylation; negative regulation of cytokinesis
Research Articles on TEX14
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Product Notes
The Human TEX14 tex14 (Catalog #AAA9338781) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338781 ELISA Kit recognizes Human TEX14. It is sometimes possible for the material contained within the vial of "testis expressed 14, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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