NCBI Description
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]
Uniprot Description
GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in the nucleus.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol
Molecular Function: enzyme inhibitor activity; protein domain specific binding; protein binding; enzyme binding; carbohydrate binding
Biological Process: negative regulation of glucokinase activity; urate metabolic process; protein import into nucleus, translocation; hexose transport; carbohydrate metabolic process; cell glucose homeostasis; pathogenesis; glucose transport; transmembrane transport; response to fructose stimulus; positive regulation of glucokinase activity
Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 5
Product Notes
The GCKR gckr (Catalog #
AAA8215916) is a Blocking Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The GCKR Blocking Peptide reacts with Human, Mouse, Rat, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's GCKR can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Researchers should empirically determine the suitability of the GCKR gckr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"GCKR, Blocking Peptide" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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absolutely not suitable for use in any
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industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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