ADAR2 Blocking Peptide | ADARB1 blocking peptide

ADAR2 Blocking Peptide

Cat. Num. AAA822775

• Gene Names: ADARB1; RED1; ADAR2; DRABA2; DRADA2
• Reactivity: Human, Mouse, Rat, Chicken, Zebrafish
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: ADAR2; ADAR2 Blocking Peptide; DRADA2; RED1; Double-stranded RNA-specific editase 1; RNA-editing deaminase 1; RNA-editing enzyme 1; dsRNA adenosine deaminase; ADARB1 blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat, Chicken, Zebrafish
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 701

• Applicable Applications for ADARB1 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for ADARB1 blocking peptide

The peptide is used to block Anti-ADAR2 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 4501919
• NCBI GeneID: 104
• NCBI Accession #: NP_001103.1
• NCBI GenBank Nucleotide #: NM_001112.3
• UniProt Accession #: P78563; O00395; O00465; O00691; O00692; P78555; A6NFK8; A6NJ84; C3TTQ1; C3TTQ2; C9JUP4; G5E9B4
• Molecular Weight: 85,669 Da
• NCBI Official Full Name: double-stranded RNA-specific editase 1 isoform 1
• NCBI Official Synonym Full Names: adenosine deaminase, RNA-specific, B1
• NCBI Official Symbol: ADARB1
• NCBI Official Synonym Symbols: RED1; ADAR2; DRABA2; DRADA2
• NCBI Protein Information: double-stranded RNA-specific editase 1; RNA editase; RED1 homolog; RNA-editing enzyme 1; RNA editing deaminase 1; RNA-editing deaminase 1; dsRNA adenosine deaminase DRADA2; adenosine deaminase, RNA-specific, B1 (RED1 homolog rat); adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)
• UniProt Protein Name: Double-stranded RNA-specific editase 1
• Protein Family: Double-stranded RNA-specific editase
• UniProt Gene Name: ADARB1
• UniProt Synonym Gene Names: ADAR2; DRADA2; RED1
• UniProt Entry Name: RED1_HUMAN

NCBI Description

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

Uniprot Description

RED1: Editing of the messenger RNAs for glutamate receptor (GluR) subunits by site-selective adenosine deamination. Edits both the GluR-B Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; EC 3.5.4.37; Hydrolase; Nucleolus

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: mRNA binding; adenosine deaminase activity; double-stranded RNA adenosine deaminase activity; protein binding; RNA binding; metal ion binding; double-stranded RNA binding

Biological Process: RNA processing; negative regulation of cell proliferation; positive regulation of viral genome replication; base conversion or substitution editing; regulation of cell cycle; mRNA modification; innate immune response; gene expression; mRNA processing; defense response to virus; adenosine to inosine editing; negative regulation of cell migration