Suppressor of tumorigenicity 14 protein homolog (St14) Recombinant Protein | St14 recombinant protein

Recombinant Mouse Suppressor of tumorigenicity 14 protein homolog (St14), partial

Cat. Num. AAA961990

• Gene Names: St14; mCAP3; MT-SP1; Prss14; Epithin; Tmprss14; matriptase
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Suppressor of tumorigenicity 14 protein homolog (St14); Recombinant Mouse Suppressor of tumorigenicity 14 protein homolog (St14); partial; St14 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 77-855
• Sequence: WHFH YRNVRVQKVF NGHLRITNEI FLDAYENSTS TEFISLASQV KEALKLLYNE VPVLGPYHKK SAVTAFSEGS VIAYYWSEFS IPPHLAEEVD RAMAVERVVT LPPRARALKS FVLTSVVAFP IDPRMLQRTQ DNSCSFALHA HGAAVTRFTT PGFPNSPYPA HARCQWVLRG DADSVLSLTF RSFDVAPCDE HGSDLVTVYD SLSPMEPHAV VRLCGTFSPS YNLTFLSSQN VFLVTLITNT DRRHPGFEAT FFQLPKMSSC GGFLSDTQGT FSSPYYPGHY PPNINCTWNI KVPNNRNVKV RFKLFYLVDP NVPVGSCTKD YVEINGEKYC GERSQFVVSS NSSKITVHFH SDHSYTDTGF LAEYLSYDSN DPCPGMFMCK TGRCIRKELR CDGWADCPDY SDERYCRCNA THQFTCKNQF CKPLFWVCDS VNDCGDGSDE EGCSCPAGSF KCSNGKCLPQ SQKCNGKDNC GDGSDEASCD SVNVVSCTKY TYRCQNGLCL SKGNPECDGK TDCSDGSDEK NCDCGLRSFT KQARVVGGTN ADEGEWPWQV SLHALGQGHL CGASLISPDW LVSAAHCFQD DKNFKYSDYT MWTAFLGLLD QSKRSASGVQ ELKLKRIITH PSFNDFTFDY DIALLELEKS VEYSTVVRPI CLPDATHVFP AGKAIWVTGW GHTKEGGTGA LILQKGEIRV INQTTCEDLM PQQITPRMMC VGFLSGGVDS CQGDSGGPLS SAEKDGRMFQ AGVVSWGEGC AQRNKPGVYT RLPVVRDWIK EHTGV
• Sequence Length: 779

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for St14 recombinant protein

This protein is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor
scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

NCBI and Uniprot Product Information

• NCBI GI #: 7363445
• NCBI GeneID: 19143
• NCBI Accession #: NP_035306.2
• NCBI GenBank Nucleotide #: NM_011176.4
• UniProt Accession #: P56677
• Molecular Weight: 94,655 Da
• NCBI Official Full Name: suppressor of tumorigenicity 14 protein homolog
• NCBI Official Synonym Full Names: suppression of tumorigenicity 14 (colon carcinoma)
• NCBI Official Symbol: St14
• NCBI Official Synonym Symbols: mCAP3; MT-SP1; Prss14; Epithin; Tmprss14; matriptase
• NCBI Protein Information: suppressor of tumorigenicity 14 protein homolog
• UniProt Protein Name: Suppressor of tumorigenicity 14 protein homolog
• Protein Family: Suppressor of tumorigenicity 14 protein
• UniProt Gene Name: St14
• UniProt Synonym Gene Names: Prss14

Uniprot Description

Degrades extracellular matrix. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing ().