Human suppressor of cytokine signaling 5 ELISA Kit | SOCS5 elisa kit
Human Suppressor of cytokine signaling 5, SOCS5 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
SOCS5: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: cytoplasm
Molecular Function: protein binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; epidermal growth factor receptor binding
Biological Process: negative regulation of epidermal growth factor receptor activity; epidermal growth factor receptor signaling pathway; negative regulation of T-helper 2 cell differentiation; regulation of growth; cytokine and chemokine mediated signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; cell growth; JAK-STAT cascade; positive regulation of T-helper 1 cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of signal transduction
Research Articles on SOCS5
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Product Notes
The Human SOCS5 socs5 (Catalog #AAA9331065) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331065 ELISA Kit recognizes Human SOCS5. It is sometimes possible for the material contained within the vial of "suppressor of cytokine signaling 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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