Rab 6A Blocking Peptide | Rab6A blocking peptide

Rab 6A (K144) Peptide

Cat. Num. AAA3004453

• Gene Names: RAB6A; RAB6
• Applications: Blocking
• Purity: Synthetic peptide Rab 6A (K144). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Rab 6A; Rab 6A (K144) Peptide; GTP binding protein RAB6A'; GTP binding protein RAB6B; Oncogene RAB6; Rab 6; Rab GTPase; RAB6; RAB6 member RAS oncogene family; RAB6A member RAS oncogene family; Rab6A variant 3; RAB6A'; RAB6B; Ras related protein Rab 6A; RCO4 3; Rab6A blocking peptide

• Specificity: This peptide can be used with studies using MBS3004452 Rab 6A (K144) pAb.
• Purity/Purification: Synthetic peptide Rab 6A (K144). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 104

• Applicable Applications for Rab6A blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Rab6A blocking peptide

Rab proteins are also an integral part of endocytic pathways. Rab 6A is a ubiquitously expressed member of the Rab family of proteins and localizes to the Golgi membrane where it regulates retrograde transport from the late endosomes via the Golgi to endoplasmic reticulum (ER) pathway. Three isoforms exist due to alternative splicing events, namely the ubiquitously expressed isoforms Rab 6A' and Rab 6A, and the brain-specific isoform Rab 6B.

NCBI and Uniprot Product Information

• NCBI GI #: 344030202
• NCBI GeneID: 5870
• NCBI Accession #: NP_001230647.1
• NCBI GenBank Nucleotide #: NP_001230647.1
• UniProt Accession #: P20340
• NCBI Official Full Name: ras-related protein Rab-6A isoform d
• NCBI Official Synonym Full Names: RAB6A, member RAS oncogene family
• NCBI Official Symbol: RAB6A
• NCBI Official Synonym Symbols: RAB6
• NCBI Protein Information: ras-related protein Rab-6A
• UniProt Protein Name: Ras-related protein Rab-6A
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB6A
• UniProt Synonym Gene Names: RAB6; Rab-6
• UniProt Entry Name: RAB6A_HUMAN

NCBI Description

This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Uniprot Description

RAB6A: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Interacts with CCDC64; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO/C1orf88. Ubiquitous. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: Golgi membrane; Golgi apparatus; membrane; trans-Golgi network; cytoplasmic vesicle; cytosol

Molecular Function: GTPase activity; protein domain specific binding; protein binding; GDP binding; GTP binding; myosin V binding

Biological Process: antigen processing and presentation; protein localization in Golgi apparatus; retrograde vesicle-mediated transport, Golgi to ER; peptidyl-cysteine methylation; protein targeting to Golgi; Rab protein signal transduction; retrograde transport, endosome to Golgi