Sheep anti-Human SH2 domain protein 2A Polyclonal Antibody | anti-SH2D2A antibody
SH2 domain protein 2A (SH2D2A, F2771, SCAP, SH2 domain-containing adapter protein, SH2 domain-containing protein 2A, T cell-specific adapter protein, TSAd, TSAD, VEGF receptor-associated protein, VRAP)
Gene Names
SH2D2A; SCAP; TSAD; VRAP; F2771
Reactivity
Human
Applications
Western Blot
Purity
Affinity PurifiedPurified by affinity chromatography.
Synonyms
SH2 domain protein 2A; Polyclonal Antibody; SH2 domain protein 2A (SH2D2A; F2771; SCAP; SH2 domain-containing adapter protein; SH2 domain-containing protein 2A; T cell-specific adapter protein; TSAd; TSAD; VEGF receptor-associated protein; VRAP); Anti -SH2 domain protein 2A (SH2D2A; anti-SH2D2A antibody
Host
Sheep
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes endogenous human SH2D2A at 52kD.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Purified by affinity chromatography.
Form/Format
Supplied as a lyophillized power in PBS, 5% Trehalose. Reconstitute with sterile 40-50% glycerol, PBS, 0.02% sodium azide.
Applicable Applications for anti-SH2D2A antibody
Western Blot (WB)
Application Notes
Dilution: Western Blot: 0.5ug/ml
Immunogen
E. coli-derived rhSH2D2A (aa279-389)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-SH2D2A antibody
SH2D2A (SH2 domain-containing protein 2A; also TSAd and VRAP) is a 52kD protein best described as a multifunctional intracellular adaptor molecule. It is expressed in activated CD4+ and CD8+ T cells, endothelial cells, and fibroblasts. SH2D2A is found in both cytoplasm and nucleus, and has multiple binding partners. After TCR activation, SH2D2A interacts with LCK, prolonging its activity. It also binds to SMAD2 and SMAD3, and constitutively interacts with PI3K and PLCg, thus participating in VEGF:KDR signaling. Human SH2D2A is 389 amino acids (aa) in length and contains one SH2 domain (aa 95-186) and a Pro-rich region (aa 187-389). Phosphorylation occurs on Y39, Y216 and Y305, and on S217 and S296.
Product Categories/Family for anti-SH2D2A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40,951 Da
NCBI Official Full Name
SH2 domain-containing protein 2A isoform 3
NCBI Official Synonym Full Names
SH2 domain containing 2A
NCBI Official Symbol
SH2D2A
NCBI Official Synonym Symbols
SCAP; TSAD; VRAP; F2771
NCBI Protein Information
SH2 domain-containing protein 2A; OTTHUMP00000038737; OTTHUMP00000038738; SH2 domain protein 2A; VEGF receptor-associated protein; T cell specific adapter protein TSAd; T lymphocyte specific adaptor protein
UniProt Protein Name
SH2 domain containing adpater protein 2 transcript variant 2
Protein Family
UniProt Gene Name
SH2D2A
UniProt Entry Name
Q5UBZ1_HUMAN
NCBI Description
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Uniprot Description
TSAd: an adaptor protein that may facilitate and regulate interaction of KDR with effector proteins important to endothelial cell survival and proliferation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway in T cells. Could also play an important role in normal and pathological angiogenesis.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding
Biological Process: cell proliferation; positive regulation of signal transduction; angiogenesis; signal transduction; vascular endothelial growth factor receptor signaling pathway; cell differentiation
Research Articles on SH2D2A
Similar Products
Product Notes
The SH2D2A sh2d2a (Catalog #AAA622587) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The SH2 domain protein 2A (SH2D2A, F2771, SCAP, SH2 domain-containing adapter protein, SH2 domain-containing protein 2A, T cell-specific adapter protein, TSAd, TSAD, VEGF receptor-associated protein, VRAP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SH2 domain protein 2A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Dilution: Western Blot: 0.5ug/ml. Researchers should empirically determine the suitability of the SH2D2A sh2d2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SH2 domain protein 2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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