Rabbit anti-Human, Mouse SASS6 Polyclonal Antibody | anti-SASS6 antibody
SASS6 Antibody
Gene Names
SASS6; SAS6; SAS-6
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SASS6; Polyclonal Antibody; SASS6 Antibody; 2810453L12Rik; FLJ22097; HsSAS 6; HsSAS6; MGC119440; RGD1306255; SAS 6; SAS6; SASS 6; Spindle assembly 6 homolog (C. elegans); Spindle assembly 6 homolog; Spindle assembly abnormal protein 6; Spindle assembly abnormal protein 6 homolog; anti-SASS6 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SASS6 Antibody detects endogenous levels of SASS6.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SASS6 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SASS6.
Conjugation
Unconjugated
Similarity
The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
Post Translational Modifications
Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during S phase, leading to its degradation and preventing centriole reduplication.
Subunit Structure
Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets (By similarity). Interacts with FBXW5. Forms a complex with CENPJ and STIL. Interacts with NUP62 and TUBG1 at the centrosome.
Function
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification.
Note
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SASS6 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
74,397 Da
NCBI Official Full Name
spindle assembly abnormal protein 6 homolog isoform 1
NCBI Official Synonym Full Names
spindle assembly 6 homolog (C. elegans)
NCBI Official Symbol
SASS6
NCBI Official Synonym Symbols
SAS6; SAS-6
NCBI Protein Information
spindle assembly abnormal protein 6 homolog; hsSAS-6
UniProt Protein Name
Spindle assembly abnormal protein 6 homolog
Protein Family
UniProt Gene Name
SASS6
UniProt Synonym Gene Names
SAS6; HsSAS-6
UniProt Entry Name
SAS6_HUMAN
Similar Products
Product Notes
The SASS6 sass6 (Catalog #AAA9631219) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SASS6 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SASS6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SASS6 sass6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SASS6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
