Rabbit anti-Human RBM24 Polyclonal Antibody | anti-RBM24 antibody

RBM24 Antibody

Cat. Num. AAA9629132

• Gene Names: RBM24; RNPC6; dJ259A10.1
• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: RBM24; Polyclonal Antibody; RBM24 Antibody; dJ259A10.1; FLJ26355; FLJ30829; FLJ37697; RBM 24; rbm24; RBM24_HUMAN; RNA binding motif protein 24; RNA binding protein 24; RNA binding region (RNP1 RRM) containing 6; RNA binding region containing protein 6; RNA-binding motif protein 24; RNA-binding protein 24; RNA-binding region-containing protein 6; RNPC6; anti-RBM24 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: RBM24 Antibody detects endogenous levels of total RBM24.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-RBM24 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The RRM domain is necessary for mRNA stability and mRNA translation regulation (PubMed:24356969, PubMed:29358667).
• Subunit Structure: Interacts with EIF4E; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex.
• Tissue Specificity: Expressed in fetal and adult heart and skeletal muscles.
• Function: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability. Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities. Involved in myogenic differentiation by regulating MYOG levels. Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization. Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence. Plays a role in the regulation of mRNA translation. Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation. Binds to a huge amount of mRNAs. Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-RBM24 antibody

Nucleus; Cytoplasm; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 221139802
• NCBI GeneID: 221662
• NCBI Accession #: NP_001137414.1
• NCBI GenBank Nucleotide #: NM_001143942.1
• UniProt Accession #: Q9BX46; Q6QDA4; Q8N9D3; Q96NI3; E9PAY4
• Molecular Weight: 24,776 Da
• NCBI Official Full Name: RNA-binding protein 24 isoform 1
• NCBI Official Synonym Full Names: RNA binding motif protein 24
• NCBI Official Symbol: RBM24
• NCBI Official Synonym Symbols: RNPC6; dJ259A10.1
• NCBI Protein Information: RNA-binding protein 24; RNA-binding motif protein 24; RNA-binding region-containing protein 6; RNA-binding region (RNP1, RRM) containing 6
• UniProt Protein Name: RNA-binding protein 24
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM24
• UniProt Synonym Gene Names: RNPC6
• UniProt Entry Name: RBM24_HUMAN

Uniprot Description

RBM24: Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA and regulates its stability. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: cytoplasm; nucleus

Molecular Function: mRNA 3'-UTR binding; nucleotide binding

Biological Process: regulation of mRNA stability; cell differentiation