Rabbit HLA-DRA Polyclonal Antibody | anti-HLA-DRA antibody

HLA-DRA

Cat. Num. AAA8562995

• Gene Names: HLA-DRA; HLA-DRA1
• Reactivity: Human; Predicted: Rat, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Purified By Antigen Affinity Column
• Synonyms: HLA-DRA; Polyclonal Antibody; Purified Rabbit Anti Human HLA-DRA Polyclonal antibody; HLA-DRA1; anti-HLA-DRA antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Rat, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified By Antigen Affinity Column
• Form/Format: Already dissolved in sterile H2O with 1% BSA and 0.02% NaN3 and 50% Glycerol.
• Sequence Length: 1251

• Applicable Applications for anti-HLA-DRA antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA: 1:20000-80000; WB: 1:200-1,000; IHC: 1:100-500
• Immunogen: Recombinant fragment corresponding to 42-216aa of human HLA-DRA.
• Cellular Localization: Membrane

Related Product Information for anti-HLA-DRA antibody

Homo sapiens major histocompatibility complex, class II, DR alpha, mRNA

References

Corte G, Damiani G, Calabi F. et al. Analysis of HLA-DR polymorphism by two-dimensional peptide mapping. Proc Natl Acad Sci USA. 78(1):534-8 (1981)

NCBI and Uniprot Product Information

• NCBI GI #: 48734718
• NCBI GeneID: 3122
• Molecular Weight: 32KD
• NCBI Official Full Name: Homo sapiens major histocompatibility complex, class II, DR alpha, mRNA
• NCBI Official Synonym Full Names: major histocompatibility complex, class II, DR alpha
• NCBI Official Symbol: HLA-DRA
• NCBI Official Synonym Symbols: HLA-DRA1
• NCBI Protein Information: HLA class II histocompatibility antigen, DR alpha chain
• Protein Family: HLA class II histocompatibility antigen

NCBI Description

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]