Rabbit CALCOCO1 Polyclonal Antibody | anti-CALCOCO1 antibody

CALCOCO1 Antibody

Cat. Num. AAA9629926

• Gene Names: CALCOCO1; Cocoa; PP13275; calphoglin
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: CALCOCO1; Polyclonal Antibody; CALCOCO1 Antibody; Calcium binding and coiled coil domain 1; Calphoglin; Coiled coil coactivator protein; Coiled coil leucine zipper coactivator 1; Coiled coil transcriptional coactivator; Inorganic pyrophosphatase activator; KIAA1536; PP13275; Sarcoma antigen NY-SAR-3; anti-CALCOCO1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: CALCOCO1 Antibody detects endogenous levels of CALCOCO1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-CALCOCO1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human CALCOCO1.
• Conjugation: Unconjugated
• Similarity: The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity). The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity). Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators. Belongs to the CALCOCO family.
• Subunit Structure: Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (Ref.1). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).
• Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells.Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
• Note: huttles between nucleus and cytoplasm.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-CALCOCO1 antibody

Cytoplasm; Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 14149742
• NCBI GeneID: 57658
• NCBI Accession #: NP_065949
• NCBI GenBank Nucleotide #: NM_020898
• UniProt Accession #: Q9P1Z2; Q6FI59; Q71RC3; Q86WF8; Q96JU3; Q9H090; B3KVA8
• Molecular Weight: 67,542 Da
• NCBI Official Full Name: calcium-binding and coiled-coil domain-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: calcium binding and coiled-coil domain 1
• NCBI Official Symbol: CALCOCO1
• NCBI Official Synonym Symbols: Cocoa; PP13275; calphoglin
• NCBI Protein Information: calcium-binding and coiled-coil domain-containing protein 1; coiled-coil coactivator protein; coiled-coil leucine zipper coactivator 1; inorganic pyrophosphatase activator; sarcoma antigen NY-SAR-3
• UniProt Protein Name: Calcium-binding and coiled-coil domain-containing protein 1
• Protein Family: Calcium-binding and coiled-coil domain-containing protein
• UniProt Gene Name: CALCOCO1
• UniProt Synonym Gene Names: KIAA1536
• UniProt Entry Name: CACO1_HUMAN