PACAP-38 Peptide | ADCYAP1R1 peptide
PACAP-38 (Pituitary Adenylate Cyclase Activating Polypeptide) (human, ovine, rat) (Biotin)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
Uniprot Description
Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Subunit structure: Interacts (via N-terminal extracellular domain) with ADCYAP1.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
Sequence similarities: Belongs to the G-protein coupled receptor 2 family.
Sequence caution: The sequence BAA04466.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on ADCYAP1R1
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Product Notes
The ADCYAP1R1 adcyap1r1 (Catalog #AAA659266) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PACAP-38, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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