Mortality Factor 4 Like 1 Recombinant Protein | MORF4L1 recombinant protein

Recombinant Human Mortality Factor 4 Like 1

Cat. Num. AAA145140

• Gene Names: MORF4L1; Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15
• Purity: Greater than 85.0% as determined by SDS-PAGE.
• Synonyms: Mortality Factor 4 Like 1; Recombinant Human Mortality Factor 4 Like 1; MORF4L1 Human; Mortality Factor 4 Like 1 Human Recombinant; Mortality factor 4-like protein 1; MORF-related gene 15 protein; Protein MSL3-1; Transcription factor-like protein MRG15; MORF4L1; MRG15; FWP006; HSPC008; HSPC061; PP368; Eaf3; MEAF3; S863-6; HsT17725; MORFRG15; MORF4L1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85.0% as determined by SDS-PAGE.
• Form/Format: MORF4L1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.15M NaCl and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAPKQD PKPKFQEGER VLCFHGPLLY EAKCVKVAIK DKQVKYFIHY SGWNKNWDEW VPESRVLKYV DTNLQKQREL QKANQEQYAE GKMRGAAPGK KTSGLQQKNV EVKTKKNKQK TPGNGDGGST SETPQPPRKK RARVDPTVEN EETFMNRVEV KVKIPEELKP WLVDDWDLIT RQKQLFYLPA KKNVDSILED YANYKKSRGN TDNKEYAVNE VVAGIKEYFN VMLGTQLLYK FERPQYAEIL ADHPDAPMSQ VYGAPHLLRL FVRIGAMLAY TPLDEKSLAL LLNYLHDFLK YLAKNSATLF SASDYEVAPP EYHRKAV.
• Sequence Length: 235

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for MORF4L1 recombinant protein

Description: MORF4L1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 347 amino acids (1-323 a.a) and having a molecular mass of 39.8kDa.MORF4L1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Mortality factor 4-like protein 1 (MORF4L1) is a member of the MRG family. MORF4L1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes mostly by acetylation of nucleosomal histones H4 and H2A. MORF4L1 is a transcription factor expressed in various human tissues, and its orthologs have been found in many other eukaryotes which comprise the MRG protein family. The C-terminal part of MORF4L1 forms a conserved MRG domain that is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein.

Product Categories/Family for MORF4L1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Mortality Factor

NCBI and Uniprot Product Information

• NCBI GI #: 388240812
• NCBI GeneID: 10933
• NCBI Accession #: NP_001252532.1
• NCBI GenBank Nucleotide #: NM_001265603.1
• UniProt Accession #: Q9UBU8; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; B4DKN6; B7Z6R1; D3DW88
• Molecular Weight: 26,750 Da
• NCBI Official Full Name: mortality factor 4-like protein 1 isoform 3
• NCBI Official Synonym Full Names: mortality factor 4 like 1
• NCBI Official Symbol: MORF4L1
• NCBI Official Synonym Symbols: Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15
• NCBI Protein Information: mortality factor 4-like protein 1; Esa1p-associated factor 3 homolog; MORF-related gene 15 protein; MORF-related gene on chromosome 15; protein MSL3-1; transcription factor-like protein MRG15
• UniProt Protein Name: Mortality factor 4-like protein 1
• Protein Family: Mortality factor 4-like protein
• UniProt Gene Name: MORF4L1
• UniProt Synonym Gene Names: MRG15
• UniProt Entry Name: MO4L1_HUMAN

Uniprot Description

MORF4L1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; Sin3 complex

Molecular Function: protein binding; protein N-terminus binding; chromatin binding

Biological Process: cell proliferation; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of growth; histone deacetylation; double-strand break repair via homologous recombination