Mouse anti-Human LSM3 Monoclonal Antibody | anti-LSM3 antibody

Anti-LSM3 Antibody, Mouse Monoclonal

Cat. Num. AAA8107392

• Gene Names: LSM3; SMX4; USS2; YLR438C
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: LSM3; Monoclonal Antibody; Anti-LSM3 Antibody; Mouse Monoclonal; LSM3 Antibody; Mouse MAb; LSM3 homolog; U6 small nuclear RNA associated (S. cerevisiae); Anti-SMX4 Antibody; Anti-USS2 Antibody; Anti-YLR438C Antibody; anti-LSM3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 01
• Specificity: Human LSM3
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-LSM3 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human LSM3 Protein
• Conjugation: Unconjugated
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human LSM3 (rh LSM3). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-LSM3 antibody

LSM3 (LSM3 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated) is a Protein Coding gene. LSM3 is a member of the snRNP Sm proteins family. It plays role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as a component of the pre-catalytic spliceosome (spliceosome B complex). Sm-like proteins can be detected in a variety of organisms. They all have the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. Diseases associated with LSM3 include Spondylolysis.

References

Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7. Lehner B. et al., 2004, Genome Res. 14 (7): 1315-23. Lehner B. et al., 2004, Genomics. 83 (1): 153-67.

NCBI and Uniprot Product Information

• NCBI GI #: 7657315
• NCBI GeneID: 27258
• NCBI Accession #: NP_055278.1
• NCBI GenBank Nucleotide #: NM_014463.2
• UniProt Accession #: P62310; Q6IAH0; Q9Y4Z1
• Molecular Weight: 11,845 Da
• NCBI Official Full Name: U6 snRNA-associated Sm-like protein LSm3
• NCBI Official Synonym Full Names: LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
• NCBI Official Symbol: LSM3
• NCBI Official Synonym Symbols: SMX4; USS2; YLR438C
• NCBI Protein Information: U6 snRNA-associated Sm-like protein LSm3
• UniProt Protein Name: U6 snRNA-associated Sm-like protein LSm3
• Protein Family: U6 snRNA-associated Sm-like protein
• UniProt Gene Name: LSM3
• UniProt Entry Name: LSM3_HUMAN

NCBI Description

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Uniprot Description

LSM3: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.

Protein type: Spliceosome; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: cytosol; nucleus

Molecular Function: protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay