Rabbit anti-Human CFD  Monoclonal Antibody | anti-CFD  antibody

Rabbit anti Human CFD  Monoclonal Antibody

Cat. Num. AAA2543864

• Gene Names: CFD; DF; ADN; PFD; ADIPSIN
• Reactivity: Human
• Applications: ELISA
• Synonyms: CFD ; Monoclonal Antibody; Rabbit anti Human CFD Monoclonal Antibody; anti-CFD antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 230

• Applicable Applications for anti-CFD antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CFD. The detection limit for Human CFD is approximately 0.0195 ng/well.
• Immunogen: Recombinant Human Adipsin/Complement Factor D protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CFD  antibody

Mouse complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to the peptidase S1 family. CFD/Adipsin contains one peptidase S1 domain. Complement factor D (CFD/Adipsin) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D (CFD/Adipsin) has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Complement factor D (CFD/Adipsin) cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D (CFD/Adipsin) is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD/Adipsin are the cause of complement factor D deficiency (CFD deficiency) which predisposes to invasive meningococcal disease.

NCBI and Uniprot Product Information

• NCBI GI #: 55249559
• NCBI GeneID: 1675
• Molecular Weight: 27,033 Da
• NCBI Official Full Name: CFD protein, partial
• NCBI Official Synonym Full Names: complement factor D
• NCBI Official Symbol: CFD
• NCBI Official Synonym Symbols: DF; ADN; PFD; ADIPSIN
• NCBI Protein Information: complement factor D
• UniProt Protein Name: Complement factor D
• UniProt Gene Name: CFD
• UniProt Synonym Gene Names: DF; PFD
• UniProt Entry Name: CFAD_HUMAN

NCBI Description

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]

Uniprot Description

CFD: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.46; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: complement activation; complement activation, alternative pathway; platelet degranulation

Disease: Complement Factor D Deficiency