Lamin-A Recombinant Protein | LMNA recombinant protein
Recombinant Human Lamin-A
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles.
NCBI and Uniprot Product Information
NCBI Description
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Uniprot Description
lamin A/C: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: nucleoplasm; nuclear lamina; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; lamin filament; intermediate filament; nuclear speck; nuclear envelope; cytosol; nucleus
Molecular Function: protein binding; structural molecule activity
Biological Process: muscle development; mitotic nuclear envelope reassembly; unfolded protein response; apoptosis; ventricular cardiac muscle cell development; mitotic nuclear envelope disassembly; regulation of cell migration; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; sterol regulatory element binding protein nuclear translocation; mitotic cell cycle; establishment and/or maintenance of microtubule cytoskeleton polarity; cell structure disassembly during apoptosis
Disease: Heart-hand Syndrome, Slovenian Type; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Restrictive Dermopathy, Lethal; Mandibuloacral Dysplasia With Type A Lipodystrophy; Muscular Dystrophy, Congenital, Lmna-related; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Charcot-marie-tooth Disease, Axonal, Type 2b1; Lipodystrophy, Familial Partial, Type 2; Hutchinson-gilford Progeria Syndrome; Cardiomyopathy, Dilated, 1a; Muscular Dystrophy, Limb-girdle, Type 1b; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism
Research Articles on LMNA
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Product Notes
The LMNA lmna (Catalog #AAA143846) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: HHHHHHMETP SQRRATRSGA QASSTPLSPT RITRLQEKED LQELNDRLAV YIDRVHSLET ENAGLRLRIT ESEEVVSREV SGIKAAYEAE LGDARKTLDS VAKERARLQL ELSKVREEFK ELKARNTKKE GDLIAAQARL KDLEALLNSK EAALSTALSE KRTLEGELHD LRGQVAKLEA ALGEAKKQLQ DEMLRRVDAE NRLQTMKEEL DFQKNIYSEE LRETKRRHET RLVEIDNGKQ REFESRLADA LQELRAQHED QVEQYKKELE KTYSAKLDNA RQSAERNSNL VGAAHEELQQ SRIRIDSLSA QLSQLQKQLA AKEAKLRDLE DSLARERDTS RRLLAEKERE MAEMRARMQQ QLDEYQELLD IKLALDMEIH AYRKLLEGEE ERLRLSPSPT SQRSRGRASS HSSQTQGGGS VTKKRKLEST ESRSSFSQHA RTSGRVAVEE VDEEGKFVRL RNKSNEDQSM GNWQIKRQNG DDPLLTYRFP PKFTLKAGQV VTIWAAGAGA THSPPTDLVW KAQNTWGCGN SLRTALINST GEEVAMRKLV RSVTVVEDDE DEDGDDLLHH HHGSHCSSSG DPAEYNLRSR TVLCGTCGQP ADKASASGSG AQVGGPISSG SSASSVTVTR SYRSVGGSGG GSFGDNLVTR S. It is sometimes possible for the material contained within the vial of "Lamin-A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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