Voltage-gated potassium channel subunit beta-1 (Kcnab1) Recombinant Protein | Kcnab1 recombinant protein

Recombinant Mouse Voltage-gated potassium channel subunit beta-1 (Kcnab1)

Cat. Num. AAA956006

• Gene Names: Kcnab1; Akr8a8; Kvbeta1.1; mKv(beta)1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Voltage-gated potassium channel subunit beta-1 (Kcnab1); Recombinant Mouse Voltage-gated potassium channel subunit beta-1 (Kcnab1); Kcnab1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-401, Full length protein
• Sequence: MQVSIACTEHNLKSRNGEDRLLSKQSSNAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS
• Sequence Length: 401

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Kcnab1 recombinant protein

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.

NCBI and Uniprot Product Information

• NCBI GI #: 148747467
• NCBI GeneID: 16497
• NCBI Accession #: NP_034727.3
• NCBI GenBank Nucleotide #: NM_010597.5
• UniProt Accession #: P63143; P97380; Q61763; Q63277; Q91WM5
• Molecular Weight: 44,723 Da
• NCBI Official Full Name: voltage-gated potassium channel subunit beta-1 isoform 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, beta member 1
• NCBI Official Symbol: Kcnab1
• NCBI Official Synonym Symbols: Akr8a8; Kvbeta1.1; mKv(beta)1
• NCBI Protein Information: voltage-gated potassium channel subunit beta-1
• UniProt Protein Name: Voltage-gated potassium channel subunit beta-1
• Protein Family: Voltage-gated potassium channel
• UniProt Gene Name: Kcnab1
• UniProt Synonym Gene Names: Kvb1

Uniprot Description

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:10454353). Modulates action potentials via its effect on the pore-forming alpha subunits (PubMed:10454353). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (PubMed:8824288). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (). Accelerates KCNA4 channel closure (). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (). Enhances KCNB1 and KCNB2 channel activity (PubMed:8824288). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (). Has NADPH-dependent aldoketoreductase activity (). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity ().