Kv1.6 Blocking Peptide | KCNA6 blocking peptide

Kv1.6 Blocking Peptide

Cat. Num. AAA9622226

• Gene Names: KCNA6; HBK2; KV1.6; PPP1R96
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: Kv1.6; Kv1.6 Blocking Peptide; KCNA6 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for KCNA6 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KCNA6 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 116434
• NCBI GeneID: 3742
• UniProt Accession #: P17658
• Molecular Weight: 58,729 Da
• NCBI Official Full Name: Potassium voltage-gated channel subfamily A member 6
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, member 6
• NCBI Official Symbol: KCNA6
• NCBI Official Synonym Symbols: HBK2; KV1.6; PPP1R96
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 6; human brain potassium channel-2; voltage-gated potassium channel HBK2; protein phosphatase 1, regulatory subunit 96; voltage-gated potassium channel protein Kv1.6; voltage-gated potassium channel subun
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 6
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNA6
• UniProt Entry Name: KCNA6_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv1.6: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: voltage-gated potassium channel activity; delayed rectifier potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport