Potassium voltage-gated channel subfamily A member 2 (Kcna2) Recombinant Protein | Kcna2 recombinant protein

Recombinant Rat Potassium voltage-gated channel subfamily A member 2 (Kcna2)

• Gene Names: Kcna2; BK2; NGK1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Potassium voltage-gated channel subfamily A member 2 (Kcna2); Recombinant Rat Potassium voltage-gated channel subfamily A member 2 (Kcna2); Recombinant Potassium voltage-gated channel subfamily A member 2 (Kcna2); Potassium voltage-gated channel subfamily A member 2; RAK RBK2 RCK5 Voltage-gated potassium channel subunit Kv1.2; Kcna2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-499
• Sequence: MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
• Sequence Length: 499

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 25742772
• NCBI GeneID: 25468
• NCBI Accession #: NP_037102.1
• NCBI GenBank Nucleotide #: NM_012970.3
• UniProt Accession #: P63142; P15386; Q02010
• Molecular Weight: 56,701 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, member 2
• NCBI Official Symbol: Kcna2
• NCBI Official Synonym Symbols: BK2; NGK1
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 2; RAK; RBK2; RCK5; voltage-gated potassium channel subunit Kv1.2; Potassium (K+) channel protein alpha 2, voltage dependent; potassium voltage gated channel shaker related subfamily member 2
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 2
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: Kcna2
• UniProt Entry Name: KCNA2_RAT

NCBI Description

delayed-rectifier K+ channel expressed in heart and brain [RGD, Feb 2006]

Uniprot Description

Kv1.2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: presynaptic membrane; endoplasmic reticulum membrane; voltage-gated potassium channel complex; lamellipodium; integral to plasma membrane; axon; dendrite; integral to membrane; perikaryon; nerve terminal; cell junction; endosome

Molecular Function: protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; outward rectifier potassium channel activity

Biological Process: optic nerve structural organization; generation of action potential; regulation of circadian sleep/wake cycle, non-REM sleep; sensory perception of pain; regulation of dopamine secretion; protein oligomerization; protein homooligomerization