Potassium voltage-gated channel subfamily A member 2 (kcna2) Recombinant Protein | kcna2 recombinant protein
Recombinant Oncorhynchus mykiss Potassium voltage-gated channel subfamily A member 2 (kcna2)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and central nervous system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (). Can form functional homotetrameric channels and heterotetrameric channels with other family members; the channels characteristics depend critically on the types of channel-forming alpha subunits that are present (). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits (). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus ().
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Product Notes
The kcna2 kcna2 (Catalog #AAA7017606) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-494aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the kcna2 kcna2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MTVATGDPSD EAAAHPGNPA EYDPDADHEC CERVVINISG LRFETQLKTL SQFPDTLLGD PKKRMRYFDP LRNEYFFDRS RTSFDAILYF YQSGGRLRRP ANVTLDIFSE EIRFYELGDE AIELFREDEG FVKEEERPLP DNEFQRQVWL LFEYPESSGP ARIIAIISVM VILISIVSFC LETLPIFRND DDEPHSVFDT NTNTTIYFTS TYFTDPFFIL ETLCIIWFSF EFLVRLFACP SKSGFFGNVM NIIDVVAIIP YFITLATELA EKPEDGQAGQ QAMSLAILRV IRLVRVFRIF KLSRHSKGLQ ILGQTLKASM RELGLLIFFL FIGVILFSSA VYFAEADEPE SQFESIPDAF WWAVVSMTTV GYGDMVPTTI GGKIVGSLCA IAGVLTIALP VPVIVSNFNY FYHRETEGEE QAQCLGPVTK EDSNEELKKS RSGSTISKSD YMEIQEGVNN TIEDIPEENL KTQANCTTLA NTNYVNITKM LTDV. It is sometimes possible for the material contained within the vial of "Potassium voltage-gated channel subfamily A member 2 (kcna2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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