AM-7209, Inhibitor
AM-7209
Purity
>98% (HPLC)
Synonyms
AM-7209; AM 7209; AM7209; inhibitor
Purity/Purification
>98% (HPLC)
Target
MDM2-p53
Receptor
MDM2-p53
Chemical Name
4-(2-((3R, 5R, 6S)-1-((S)-2-(tert-Butylsulfonyl)-1-cyclopropylethyl)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3- methyl-2-oxopiperidin-3-yl)acetamido)-2-methoxybenzoic Acid
SMILES
O=C(O)C1=CC=C(NC(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)=O)C=C1OC
Molecular Formula
C37H41Cl2FN2O7S
CAS Number
1623432-51-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for AM-7209, inhibitor
A potent and selective inhibitor of the MDM2-p53 interaction with Kd of 38 pM, and IC50 of 1.6nM; potently inhibits cell growth on-target in the tumor cell line with wild-type p53 cell with IC50 of 2nM, exhibits >12, 500-fold selectivity over those with p53-deficient cells; demonstrates remarkable pharmacokinetic properties and in vivo antitumor activity in both the SJSA-1 osteosarcoma xenograft model (ED50=2.6mg/kg QD) and the HCT-116 colorectal carcinoma xenograft model (ED50=10mg/kg QD).
Product Categories/Family for AM-7209, inhibitor
References
1. Rew Y, et al. J Med Chem. 2014 Dec 26; 57 (24):10499-511.
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Product Notes
The AM-7209 (Catalog #AAA3602395) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AM-7209, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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