MKK6 elisa kit
MKK6 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Description
MKK6: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 17q24.3
Cellular Component: cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus
Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process: activation of MAPK activity; activation of protein kinase activity; apoptosis; cardiac muscle contraction; cell cycle arrest; DNA damage induced protein phosphorylation; MAPK cascade; nucleotide-binding oligomerization domain containing signaling pathway; ovulation cycle process; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; regulation of apoptosis; regulation of mitotic cell cycle; regulation of transcription, DNA-templated; response to drug; signal transduction; stress-activated protein kinase signaling pathway; transcription, DNA-dependent
Research Articles on MKK6
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Product Notes
The Human, Mouse, Rat MKK6 map2k6 (Catalog #AAA9500388) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500388 ELISA Kit recognizes Human, Mouse, Rat MKK6. It is sometimes possible for the material contained within the vial of "MKK6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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