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MKK3 elisa kit

Phospho-MKK3 (Thr222) Colorimetric Cell-Based ELISA Kit

Gene Names
MAP2K3; MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
Reactivity
Human, Mouse, Rat
Synonyms
MKK3; Phospho-MKK3 (Thr222) Colorimetric Cell-Based ELISA Kit; dual specificity mitogen-activated protein kinase kinase 3; kinase MKK3; MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MEK3; MP2K3; PRKMK3; MKK3 elisa kit
Ordering
For Research Use Only!
Reactivity
Human, Mouse, Rat
Form/Format
Two 96-Well Plates
Sequence Length
318
Samples
Researchers plate their cell line of choice
Assay Type
Phospho Cell-Based ELISA
Sensitivity
>=5000 cells/well
Reactivity Note
Human: T222, Mouse: T222, Rat: T222
Detection Method
Colorimetric 450 nm
Preparation and Storage
Store at 4 degree C.
Product Categories/Family for MKK3 elisa kit

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39318
NCBI Official Full Name
dual specificity mitogen-activated protein kinase kinase 3 isoform A
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase 3
NCBI Official Symbol
MAP2K3
NCBI Official Synonym Symbols
MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
NCBI Protein Information
dual specificity mitogen-activated protein kinase kinase 3
UniProt Protein Name
Dual specificity mitogen-activated protein kinase kinase 3
UniProt Gene Name
MAP2K3
UniProt Synonym Gene Names
MEK3; MKK3; PRKMK3; SKK2; MAP kinase kinase 3; MAPKK 3; MEK 3; SAPK kinase 2; SAPKK-2; SAPKK2

NCBI Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MKK3: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. A deletion and two point mutants found in colon cancer cell lines. Three splice-variant isoforms have been described.

Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm

Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity

Biological Process: activation of MAPK activity; activation of protein kinase activity; cardiac muscle contraction; inflammatory response; MAPK cascade; peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of transcription, DNA-templated; regulation of apoptosis; regulation of cytokine biosynthetic process; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling pathway

Research Articles on MKK3

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Product Notes

The Human, Mouse, Rat MKK3 map2k3 (Catalog #AAA9501630) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501630 ELISA Kit recognizes Human, Mouse, Rat MKK3. It is sometimes possible for the material contained within the vial of "MKK3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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