MEK1/2 elisa kit
Phospho-MEK1/2 (Ser221) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Uniprot Description
MEK1: a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf, Mos and Cot kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK1 and ERK2. An essential component of MAP kinase signal transduction pathways involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytosol; early endosome; endoplasmic reticulum; extracellular exosome; focal adhesion; Golgi apparatus; late endosome; microtubule organizing center; mitochondrion; nucleus; plasma membrane
Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein C-terminus binding; protein kinase activity; protein N-terminus binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
Biological Process: activation of MAPK activity; Bergmann glial cell differentiation; cell cycle arrest; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; ERK1 and ERK2 cascade; heart development; keratinocyte differentiation; MAPK cascade; negative regulation of cell proliferation; negative regulation of gene expression; neuron differentiation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of axonogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of protein serine/threonine kinase activity; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; regulation of apoptosis; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of mitotic cell cycle; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development
Disease: Cardiofaciocutaneous Syndrome 3; Noonan Syndrome 1
Research Articles on MEK1/2
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Product Notes
The Human, Mouse, Rat MEK1/2 map2k1 (Catalog #AAA9501504) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501504 ELISA Kit recognizes Human, Mouse, Rat MEK1/2. It is sometimes possible for the material contained within the vial of "MEK1/2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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