EEF2 elisa kit
eEF2 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Uniprot Description
EEF2: a member of the GTP-binding translation elongation factor family. An essential factor for protein synthesis. Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by eEF2 kinase phosphorylation. eEF2 kinase is normally dependent on Ca2+ ions and calmodulin. eEF2 kinase can also be activated by PKA in response to elevated cAMP levels, which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation.
Protein type: Translation; Translation elongation
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: aggresome; cytoplasm; cytosol; extracellular exosome; extracellular matrix; extracellular region; ficolin-1-rich granule lumen; intracellular ribonucleoprotein complex; membrane; membrane raft; nucleus; plasma membrane; polysomal ribosome; secretory granule lumen
Molecular Function: 5S rRNA binding; actin filament binding; cadherin binding; GTP binding; GTPase activity; p53 binding; protein binding; protein kinase binding; ribosome binding; RNA binding; translation elongation factor activity
Biological Process: aging; cellular response to brain-derived neurotrophic factor stimulus; glial cell proliferation; hemopoietic progenitor cell differentiation; neutrophil degranulation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; positive regulation of cytoplasmic translation; positive regulation of translation; protein amino acid methylation; response to drug; response to estradiol; response to ethanol; response to folic acid; response to hydrogen peroxide; skeletal muscle contraction; translational elongation
Disease: Spinocerebellar Ataxia 26
Research Articles on EEF2
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Product Notes
The Human, Mouse, Rat EEF2 eef2 (Catalog #AAA9500189) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500189 ELISA Kit recognizes Human, Mouse, Rat EEF2. It is sometimes possible for the material contained within the vial of "eEF2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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