Human Voltage gated potassium channel subunit beta-2, KCNAB2/KCNK2 ELISA Kit | KCNAB2/KCNK2 elisa kit
Human Voltage gated potassium channel subunit beta-2, KCNAB2/KCNK2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
Uniprot Description
Kv-beta2: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.4. Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: microtubule; voltage-gated potassium channel complex; extrinsic to internal side of plasma membrane; membrane; plasma membrane; cytosol
Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity; aldo-keto reductase activity
Biological Process: synaptic transmission; protein heterooligomerization; hemopoietic progenitor cell differentiation
Research Articles on KCNAB2/KCNK2
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Product Notes
The Human KCNAB2/KCNK2 kcnab2 (Catalog #AAA9306352) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9306352 ELISA Kit recognizes Human KCNAB2/KCNK2. It is sometimes possible for the material contained within the vial of "Voltage gated potassium channel subunit beta-2, KCNAB2/KCNK2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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