Hsp22 recombinant protein

Recombinant Human Hsp22

Cat. Num. AAA197039

• Gene Names: HSPB8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22
• Purity: Greater than 95% as determined by SDS-PAGE.
• Synonyms: Hsp22; Recombinant Human Hsp22; Hsp22 recombinant protein

• Host: E Coli
• Specificity: Human Hsp22
• Purity/Purification: Greater than 95% as determined by SDS-PAGE.
• Form/Format: White powder lyophilized from a 1mg/ml sterile-filtered solution in 20mM Tris-acetate buffer, pH 7.6, 10mM NaCl, 0.1mM EDTA, 0.1mM PMSF, and 15mM beta-mercaptoethanol. Purified by proprietary chromatographic techniques.

• Solubility: Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed.
• Preparation and Storage: Store at or below -20 degree C. After reconstitution, store at 4 degree C for up to one week and at or below -20 degree C for future use. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.

Related Product Information for Hsp22 recombinant protein

Hsp22, a Mn+2-dependent serine threonine-specific protein kinase displays temperature-dependent chaperone activity. Defects in Hsp22 cause distal hereditary motor neuropathy type 2 (also known as distal spinal muscular atrophy) and spinal muscular atrophy of the charcot-marietooth type.

NCBI and Uniprot Product Information

• NCBI GI #: 7657146
• NCBI GeneID: 26353
• NCBI Accession #: NP_055180.1
• NCBI GenBank Nucleotide #: NM_014365.2
• UniProt Accession #: Q9UJY1; Q6FIH3; Q9UKS3; B2R6A6
• Molecular Weight: 21,604 Da
• NCBI Official Full Name: heat shock protein beta-8
• NCBI Official Synonym Full Names: heat shock 22kDa protein 8
• NCBI Official Symbol: HSPB8
• NCBI Official Synonym Symbols: H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22
• NCBI Protein Information: heat shock protein beta-8; OTTHUMP00000239768; protein kinase H11; alpha-crystallin C chain; E2-induced gene 1 protein; heat shock 27kDa protein 8; small stress protein-like protein HSP22
• UniProt Protein Name: Heat shock protein beta-8
• Protein Family: Heat shock protein
• UniProt Gene Name: HSPB8
• UniProt Synonym Gene Names: CRYAC; E2IG1; HSP22
• UniProt Entry Name: HSPB8_HUMAN

NCBI Description

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq]

Uniprot Description

HSPB8: Displays temperature-dependent chaperone activity. Monomer. Interacts with HSPB1. Interacts with DNAJB6. By 17-beta-estradiol. Predominantly expressed in skeletal muscle and heart. Belongs to the small heat shock protein (HSP20) family.

Protein type: Heat shock protein

Chromosomal Location of Human Ortholog: 12q24.23

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; intracellular; nucleus

Molecular Function: identical protein binding; protein binding; protein kinase activity

Disease: Charcot-marie-tooth Disease, Axonal, Type 2l; Neuronopathy, Distal Hereditary Motor, Type Iia