Goat Troponin I, Peptide 3 Antibody | anti-TNNI1 antibody

Goat anti-Troponin I, Peptide 3, Affinity Pure (Amino Acid Sequence 27-40)

Cat. Num. AAA686080

• Gene Names: TNNI1; TNN1; SSTNI
• Reactivity: Troponin I (Human Cardiac)-(Amino Acid Sequence 27-40)
• Applications: Western Blot, ELISA
• Purity: >95% based on HPLC; Affinity purified using solid-phase peptide 3 (-RAYATEPHAKKKS-).
• Synonyms: Troponin I; Peptide 3; Goat anti-Troponin I; Affinity Pure (Amino Acid Sequence 27-40); anti-TNNI1 antibody

• Host: Goat
• Reactivity: Troponin I (Human Cardiac)-(Amino Acid Sequence 27-40)
• Specificity: Human Cardiac Troponin I (cTNI) (Amino Acid Sequence 67-79)
• Purity/Purification: >95% based on HPLC; Affinity purified using solid-phase peptide 3 (-RAYATEPHAKKKS-).
• Form/Format: Clear, colorless liquid, 0.2 um filtered
• Concentration: 4-6 mg/ml (varies by lot)
• Sequence Length: 187

• Applicable Applications for anti-TNNI1 antibody: Western Blot (WB), ELISA (EIA)
• Conjugate: UnConjugated
• Immunogen: Purified Human Cardiac Troponin, I subunit (Part# Hu-090-M)
• Buffer: 10 mM Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Preservative: 0.05% (w/v) Sodium Azide
• Preparation and Storage: Store at 2-8 degree C.; Shelf Life: 36 Months

Product Categories/Family for anti-TNNI1 antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 56682969
• NCBI GeneID: 7135
• NCBI Accession #: NP_003272.3
• NCBI GenBank Nucleotide #: NM_003281.3
• UniProt Accession #: P19237; Q659A5; Q6FGS7; Q6FGW1; Q6ICU2; Q86T57; Q96DT9; A6NEH3; A8MSJ0
• Molecular Weight: 21,692 Da
• NCBI Official Full Name: troponin I, slow skeletal muscle
• NCBI Official Synonym Full Names: troponin I1, slow skeletal type
• NCBI Official Symbol: TNNI1
• NCBI Official Synonym Symbols: TNN1; SSTNI
• NCBI Protein Information: troponin I, slow skeletal muscle
• UniProt Protein Name: Troponin I, slow skeletal muscle
• Protein Family: Troponin
• UniProt Gene Name: TNNI1

NCBI Description

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]

Uniprot Description

TNNI1: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin I family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytosol; troponin complex

Molecular Function: protein binding

Biological Process: cardiac muscle contraction; muscle filament sliding; skeletal muscle contraction