Human guanine nucleotide binding protein (G protein) , beta polypeptide 3 ELISA Kit | GNB3 elisa kit

Human Guanine nucleotide-binding protein G, GNB3 ELISA Kit

Cat. Num. AAA9320405

• Reactivity: Human
• Synonyms: guanine nucleotide binding protein (G protein); beta polypeptide 3; Human Guanine nucleotide-binding protein G; GNB3 ELISA Kit; Human Guanine nucleotide-binding protein G (GNB3) ELISA kit; G protein; beta-3 subunit; GTP-binding regulatory protein beta-3 chain; guanine nucleotide-binding protein G (I) /G (S) /G (T) beta subunit 3; guanine nucleotide-binding protein; hypertensi; GNB3 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 0.25ng/ml-8ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for GNB3 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of GNB3 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 4504053
• NCBI GeneID: 2784
• NCBI Accession #: NP_002066.1
• NCBI GenBank Nucleotide #: NM_002075.3
• UniProt Accession #: P16520; Q96B71; Q9BQC0
• Molecular Weight: 37,221 Da
• NCBI Official Full Name: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), beta polypeptide 3
• NCBI Official Symbol: GNB3
• NCBI Protein Information: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; transducin beta chain 3; G protein, beta-3 subunit; hypertension associated protein; GTP-binding regulatory protein beta-3 chain; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
• UniProt Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
• UniProt Gene Name: GNB3
• UniProt Entry Name: GBB3_HUMAN

NCBI Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

Uniprot Description

G-beta 3: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2. Belongs to the WD repeat G protein beta family.

Protein type: G protein, heterotrimeric; G protein, heterotrimeric beta; G protein

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: neuron projection; plasma membrane

Molecular Function: GTPase activity; signal transducer activity; protein binding; GTPase binding; spectrin binding

Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; regulation of blood pressure; energy reserve metabolic process

Disease: Hypertension, Essential