Fibroblast Growth Factor 17 Active Protein | FGF17 active protein

Recombinant Human Fibroblast Growth Factor 17

Cat. Num. AAA146096

• Gene Names: FGF17; HH20; FGF-13; FGF-17
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Synonyms: Fibroblast Growth Factor 17; Recombinant Human Fibroblast Growth Factor 17; FGF17 Human; Fibroblast Growth Factor 17 Human Recombinant; Fibroblast growth factor 17; FGF-17; FGF17; FGF-13; HH20; FGF17 active protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Form/Format: FGF17 protein was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: MTQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT
• Sequence Length: 216

• Solubility: It is recommended to reconstitute the lyophilized FGF17 in sterile 18M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0 x 100,000 IU/mg.
• Preparation and Storage: Lyophilized FGF17 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF17 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Related Product Information for FGF17 active protein

Description: FGF17 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 195 amino acids and having a molecular mass of 22.6kDa.

Introduction: Fibroblast Growth Factor 17 (FGF17) belongs to the fibroblast growth factor (FGF) family. FGF family members have broad mitogenic and cell survival activities, and are involved in various biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. The FGF17 gene is highly expressed in the cerebellum and cortex. The mouse homolog of the FGF17 gene is localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, suggesting a role in central nervous system, bone and vascular development.

Product Categories/Family for FGF17 active protein

Cytokines and Growth Factors; Growth Factors; Fibroblast Growth Factor

NCBI and Uniprot Product Information

• NCBI GI #: 4503693
• NCBI GeneID: 8822
• NCBI Accession #: NP_003858.1
• NCBI GenBank Nucleotide #: NM_003867.3
• UniProt Accession #: O60258; Q2M2W1; B7ZLG4
• Molecular Weight: 23,669 Da
• NCBI Official Full Name: fibroblast growth factor 17 isoform 1
• NCBI Official Synonym Full Names: fibroblast growth factor 17
• NCBI Official Symbol: FGF17
• NCBI Official Synonym Symbols: HH20; FGF-13; FGF-17
• NCBI Protein Information: fibroblast growth factor 17
• UniProt Protein Name: Fibroblast growth factor 17
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF17
• UniProt Synonym Gene Names: FGF-17
• UniProt Entry Name: FGF17_HUMAN

NCBI Description

This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Description

FGF17: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; type 2 fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; cell-cell signaling; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; signal transduction

Disease: Hypogonadotropic Hypogonadism 20 With Or Without Anosmia