Human dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 2 ELISA Kit | DYRK2 elisa kit
Human Dual specificity tyrosine-phosphorylation-regulated kinase 2, DYRK2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Uniprot Description
DYRK2: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3.
Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor); CMGC group; DYRK family; Dyrk2 subfamily
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: nucleoplasm; cytoplasm; nucleus; ribonucleoprotein complex; ubiquitin ligase complex
Molecular Function: protein serine/threonine kinase activity; protein binding; ubiquitin binding; protein-tyrosine kinase activity; manganese ion binding; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding
Biological Process: smoothened signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of glycogen biosynthetic process; negative regulation of NFAT protein import into nucleus; protein amino acid phosphorylation; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
Research Articles on DYRK2
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Product Notes
The Human DYRK2 dyrk2 (Catalog #AAA9329252) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329252 ELISA Kit recognizes Human DYRK2. It is sometimes possible for the material contained within the vial of "dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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