Dystrophin (DMD) Recombinant Protein | DMD recombinant protein
Recombinant Chicken Dystrophin (DMD), partial
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Dystrophin (DMD); Recombinant Chicken Dystrophin (DMD); partial; DMD recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-247aa; Partial(include Actin-binding Region).
Sequence
MSAHVLWYEEVEDDYEREDVQKKTFTKWINAQFAKCGRRCIEDLFNDFRDGRKLLELLECLTGQKIAKEKGSTRVHALNNVNKALQILQRNNVDLVNIGSSDIVDGNHKLTLGLIWNIILHWQVKDVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTSSWSDGLAFNALLHSHRPDLFDWNAVASQQSPVQRLDHAFNIARQHLGIEKLLDPEDVATACPDKKSILMYVTSLFQVLPQQV
Species
Chicken
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for DMD recombinant protein
The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
422,881 Da
NCBI Official Full Name
dystrophin
NCBI Official Synonym Full Names
dystrophin
NCBI Official Symbol
DMD
NCBI Protein Information
dystrophin
UniProt Protein Name
Dystrophin
Protein Family
UniProt Gene Name
DMD
Uniprot Description
May play a role in anchoring the cytoskeleton to the plasma membrane.
Research Articles on DMD
1. Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.
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Product Notes
The DMD dmd (Catalog #AAA949765) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-247aa; Partial(include Actin-binding Region). The amino acid sequence is listed below: MSAHVLWYEE VEDDYEREDV QKKTFTKWIN AQFAKCGRRC IEDLFNDFRD GRKLLELLEC LTGQKIAKEK GSTRVHALNN VNKALQILQR NNVDLVNIGS SDIVDGNHKL TLGLIWNIIL HWQVKDVMKN IMAGLQQTNS EKILLSWVRQ STRNYPQVNV INFTSSWSDG LAFNALLHSH RPDLFDWNAV ASQQSPVQRL DHAFNIARQH LGIEKLLDPE DVATACPDKK SILMYVTSLF QVLPQQV. It is sometimes possible for the material contained within the vial of "Dystrophin (DMD), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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