Bovine Dopamine Transporter ELISA Kit | DAT elisa kit
Bovine Dopamine Transporter ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
Uniprot Description
DAT: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI). It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p15.3
Cellular Component: cell soma; integral to plasma membrane; axon; cytoplasm; integral to membrane; plasma membrane
Molecular Function: protein binding; protease binding; protein complex binding; dopamine binding; monoamine transmembrane transporter activity; protein N-terminus binding; dopamine:sodium symporter activity; drug binding; dopamine transmembrane transporter activity; receptor binding
Biological Process: response to drug; lactation; response to nicotine; dopamine transport; response to cAMP; dopamine catabolic process; prepulse inhibition; sensory perception of smell; regulation of dopamine metabolic process; monoamine transport; locomotory behavior; positive regulation of multicellular organism growth; dopamine biosynthetic process; response to cocaine; synaptic transmission; response to ethanol; neurotransmitter transport; adenohypophysis development; transmembrane transport; response to iron ion; aging; neurotransmitter biosynthetic process
Disease: Parkinsonism-dystonia, Infantile; Tobacco Addiction, Susceptibility To